A 38-year-old man developed atypical hemolytic uremic syndrome (aHUS) and end-stage kidney disease (ESKD) after receiving his first dose of AstraZeneca’s COVID-19 vaccine, according to a case report. The patient was admitted to a hospital in Saudi Arabia one week after being vaccinated. Tests revealed changes in blood parameters…
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For the first time in South Korea, a patient who developed atypical hemolytic uremic syndrome (aHUS) after undergoing a kidney transplant was successfully treated with Soliris (eculizumab). “We report the first successful case of aHUS treatment in a kidney transplant recipient with early use of [Soliris] in South…
Preventive treatment with Soliris (eculizumab) before surgery dramatically improved kidney transplant outcomes in people with atypical hemolytic uremic syndrome (aHUS), according to a recent study. One year after the surgeries, 97% of transplanted kidneys still functioned in Soliris-treated patients. In those who did not receive preventive treatment, that…
A woman in her mid-30s with a twin pregnancy was diagnosed with atypical hemolytic uremic syndrome (aHUS) after she experienced complications following delivery by cesarean section. Two healthy girls were born, and the mother’s condition improved following treatment. But researchers noted that “this report underlines how crucial it is…
About half of the atypical hemolytic uremic syndrome (aHUS) patients had clinically relevant anxiety and more than a quarter met the criteria for post-traumatic stress disorder (PTSD), according to a recent study. “Our cross-sectional survey done a median of [six] years after acute … aHUS demonstrated a substantial burden…
COVID-19 may have triggered a relapse of atypical hemolytic uremic syndrome (aHUS) in a 31-year-old Japanese woman who was previously undiagnosed, according to a recent case study. The relapse occurred while the woman was positive for SARS-CoV-2, the virus that causes COVID-19, and was accompanied by disseminated, or diffuse,…
Soliris (eculizumab) was effective in managing atypical hemolytic uremic syndrome (aHUS), which arose in a man as a side effect of chemotherapy treatment with gemcitabine. “The mainstay management decision [for gemcitabine-related aHUS] is the prompt discontinuation of gemcitabine therapy, and while this is effective in some patients, complement…
A 68-year-old man was diagnosed with atypical hemolytic uremic syndrome (aHUS) that, in an “extremely rare case,” appeared to have been triggered by acute pancreatitis, or inflammation of the pancreas, according to a recent case report. The patient was admitted to a hospital…
CFH-CFHR1 hybrid genes resulting from an abnormal combination of two genes were identified in a pair of Japanese patients with atypical hemolytic uremic syndrome (aHUS). The genetic variations weren’t observed in healthy people, suggesting aHUS might be related to the hybrid genes being present. “Our study emphasizes that the…
Two identical twins have the same disease-linked mutation in the complement factor B (CFB) gene, but only one developed atypical hemolytic uremic syndrome (aHUS), a recent study reports. Despite only one having aHUS, the identical, or monozygotic, twins had similar levels of complement system activity — a part of…
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