Marisa Wexler, MS, senior science writer —

The case of a 49-year-old man with atypical hemolytic uremic syndrome (aHUS) that manifested after he developed pancreatitis was described in a recent report. Genetic testing showed the man had a mutation in the MCP gene, a known risk factor for aHUS. The fact that he hadn’t had any…

In cases of atypical hemolytic uremic syndrome (aHUS) that develop following pregnancy and childbirth, getting an early diagnosis is important for appropriate and timely treatment and better outcomes, a case report highlights. “A prompt and accurate diagnosis is critical in these patients to initiate early treatment, which can significantly…

The case of a woman who developed atypical hemolytic uremic syndrome (aHUS) following pregnancy highlights the importance of an early diagnosis and prompt treatment of the disease. As many as 20% of aHUS cases occur in people who are pregnant or have just given birth, referred to as…

Complement-blocking medications like Soliris (eculizumab) can be effective for controlling atypical hemolytic uremic syndrome (aHUS) in patients carrying a genetic variant called the MCPggaac haplotype, a new study reports. Researchers in Southeastern Europe reviewed the cases of 14 children in the region with aHUS to determine the best…

The safety profile of Soliris (eculizumab) in real-world practice is similar to that reported in clinical trials, according to a large analysis of data from Japan. “This is the largest safety dataset on [Soliris] in Japan derived from more than 10 years of clinical experience,” the researchers wrote. “No…

Most patients and caregivers living with atypical hemolytic uremic syndrome (aHUS) prefer Ultomiris (ravulizumab-cwvz) over Soliris (eculizumab), a new study reports. The fact that Ultomiris is administered less often than Soliris was viewed as a key factor that separates the two medications and patients on Ultomiris were…

A case study of atypical hemolytic uremic syndrome (aHUS) caused by a new mutation in the DGKE gene highlights the disease’s early onset and severe difficult-to-treat course. The report, “Clinical features and management of atypical hemolytic uremic syndrome patient with DGKE gene variants: a case report,”…

A young adult with atypical hemolytic uremic syndrome (aHUS) in India successfully received a transplanted kidney from a donor with an incompatible blood type, a recent case study says. The report — the first to document such a case in someone diagnosed with aHUS — demonstrates that blood-type-incompatible…

A boy with atypical hemolytic uremic syndrome (aHUS) experienced a disease relapse followed by unusual symptoms, including bone tissue death and gallstones, after pausing treatment with Soliris (eculizumab). His case was described in the report, “Bilateral hip osteonecrosis and cholelithiasis after eculizumab discontinuation in atypical…

People with atypical hemolytic uremic syndrome (aHUS) who start treatment with Soliris (eculizumab) or Ultomiris (ravulizumab) — both marketed by Alexion — generally use fewer healthcare resources, according to a new U.S. study. Indeed, rates of insurance claims for aHUS patients starting on either therapy dropped substantially…