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A 29-year-old woman in the U.S. showed signs of atypical hemolytic uremic syndrome (aHUS) and a C2 gene mutation, but without infection caused by Shiga toxin-producing Escherichia coli (STEC), according to a case report. STEC bacteria are the cause of the typical form of the disease. Genetic testing could…

Switching from Soliris (eculizumab) to Ultomiris (ravulizumab) is a safe and effective treatment strategy for people with atypical hemolytic uremic syndrome (aHUS), according to a real-world study in Japan. The treatment switch was associated with stable levels of blood and kidney-related disease markers, preventing disease relapse or…

More than half of Chinese children with atypical hemolytic uremic syndrome (aHUS) have self-reactive antibodies targeting complement factor H, a protein that regulates the activity of the immune complement cascade, a study showed. In turn, predisposing genetic mutations were detected in only 20% of the more than 100 children with aHUS…

Atypical hemolytic uremic syndrome (aHUS) may be triggered by acute inflammation of the pancreas, or pancreatitis, a team of researchers from India highlighted in a report describing the case of a 36-year-old man with both conditions. The man sought medical attention due to abdominal pain and was found to…

More than half of people with atypical hemolytic uremic syndrome (aHUS) in India have self-reactive antibodies targeting complement factor H (CFH), a protein that regulates the activity of the complement system, according to a recent study. These patients generally had better outcomes, being less likely to develop end-stage…

A woman in Italy developed atypical hemolytic uremic syndrome (aHUS) as a result of a blood cancer, which resolved after the cancer was brought into remission, a case study shows. The report, “Marginal zone lymphoma with anti-factor H IgM and atypical hemolytic uremic syndrome successfully treated…

A 47-year-old man developed atypical hemolytic uremic syndrome (aHUS) after using cocaine, but ultimately recovered before his condition led to long-term kidney damage, according to a case report in Spain. While past reports have linked aHUS to cocaine use, such cases are uncommon. The man described in the report…

Inflammation of the pancreas, known as pancreatitis, can occur alongside the rare disease atypical hemolytic uremic syndrome (aHUS) — as a team of researchers from China highlighted in a new report outlining the case of a young woman found to have both conditions. The woman sought medical attention due…

Soliris (eculizumab) helped control atypical hemolytic uremic syndrome (aHUS) in a patient whose symptoms included seizures and signs of neurological damage, according to a case report. The researchers said the case points to “the importance of timely diagnosis and treatment of aHUS as well as the…

Soliris (eculizumab) is safe and effective for treating children with various types of hemolytic uremic syndrome (HUS), including atypical HUS (aHUS), according to a real-world study involving pediatric patients in Israel. In fact, more than half of the children with aHUS given Soliris in the study achieved a…