Newly Diagnosed: Treatment Strategies for aHUS

While there is no cure for aHUS yet, there are therapeutic approaches that can help to ease symptoms and improve quality of life. Experimental treatments are also being explored that could prove beneficial for patients. Check out the information below to explore more about therapeutic strategies your doctor may recommend and what therapies are in the pipeline for potential future use.

Approved Treatments

There is no cure for aHUS yet, but there are approved medications that can help manage the symptoms of the disease, including Soliris (eculizumab) and Ultomiris (ravulizumab-cwvz). Soliris is an antibody-based therapy that works by binding to a specific component of the complement cascade, preventing the overactivation of the complement system. Ultomiris has a similar mechanism of action, but it has been modified to last longer in the body, allowing for less frequent dosing.

Experimental Treatments

Researchers are continuing to investigate other ways to treat aHUS and its symptoms. One of these experimental therapies, TX200, is intended to promote the acceptance of kidney transplants in people with end-stage renal disease. In more severe cases of aHUS, patients may develop end-stage kidney disease, in which the only option is dialysis or a kidney transplant. TX200 has the potential to help these patients in the event a transplant becomes necessary.