Treatment with Ultomiris (ravulizumab) successfully prevented disease recurrence in a middle-aged man whose atypical hemolytic uremic syndrome (aHUS) was linked to a novel mutation — one believed to put him at a high risk for relapse — in the CFH gene, a case report from Japan shows. During the…
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Ultomiris (ravulizumab) is a safe and effective way to prevent disease recurrence in people with atypical hemolytic uremic syndrome (aHUS) who undergo a kidney transplant, a real-world study in Spain shows. Data from 68 adult patients found that six months of treatment led to significant improvements in blood…
Starting treatment with Ultomiris (ravulizumab) led to rapid clinical improvement — with recovery of kidney function — for a young man with a history of kidney transplant who developed atypical hemolytic uremic syndrome (aHUS) after a severe viral lung infection. According to a report detailing the case, the…
Acute inflammation of the pancreas, or pancreatitis, induced by alcohol abuse triggered atypical hemolytic uremic syndrome (aHUS) in a 43-year-old man, a team of U.S. researchers reported. The man, with a history of alcohol abuse, sought medical attention due to abdominal pain and nausea and was found to have pancreatitis.
Children and adults in the Netherlands with atypical hemolytic uremic syndrome (aHUS) experience differences in clinical presentation and outcomes despite carrying the same disease-linked genetic variant, according to a new study. Children with this variant presented with more profound blood cell abnormalities but milder kidney impairment than adult patients.
Two brothers carrying identical genetic variants associated with atypical hemolytic uremic syndrome (aHUS) and hereditary thrombotic thrombocytopenic purpura (TTP) developed different disease manifestations, as reported in a case series. TTP is a blood disorder, like aHUS, characterized by thrombotic microangiopathy (TMA), in which blood clots form in tiny…
Complement inhibitors helped a woman partially recover from atypical hemolytic uremic syndrome (aHUS) related to pregnancy despite a five-week delay in starting treatment, according to a case report. Symptoms of kidney damage developed during the 29-year-old’s third trimester. As a result, the woman began regular hemodialysis, a procedure that…
People with atypical hemolytic uremic syndrome (aHUS) without a clear genetic cause may have rare mutations in overlooked parts of complement system genes, a new study from Europe suggests. The researchers found that one such mutation in the CFI gene — a known aHUS risk gene — greatly reduced…
A woman with atypical hemolytic uremic syndrome (aHUS) successfully underwent a second kidney transplant as treatment with Soliris (eculizumab) largely prevented or eased the complications that led to failure of her first transplant. The medication has helped stabilize the woman’s kidney function for four years, researchers wrote in a…
A COVID-19 infection apparently triggered the development of atypical hemolytic uremic syndrome (aHUS) in a 75-year-old man who had recently received a kidney transplant, according to a case report. Treatment with Ultomiris (ravulizumab) helped resolve his symptoms, supporting the use of the medication post-kidney transplant. Some kidney transplant…
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