Patricia Inácio, PhD, science writer —

At the onset of atypical hemolytic uremic syndrome (aHUS), patients are already showing signs of severe kidney injury, regardless of the specific triggers or disease-related clinical conditions they might also harbor, a registry study has found. Cancer, pregnancy, and acute infections were identified as the most common triggers before…

A 78-year-old woman developed atypical hemolytic uremic syndrome (aHUS) and acute kidney failure after contracting an infection with SARS-CoV-2, the virus that causes COVID-19, doctors wrote in a case study. Diffuse alveolar hemorrhage, a condition characterized by bleeding from the lung’s alveoli, or the tiny air sacs where gas…

A rare mutation in the CFI gene affects the risk and clinical severity of various forms of hemolytic uremic syndrome (HUS), including atypical HUS (aHUS), according to a recent study. The study, “Hot Spot of Complement Factor I Rare Variant p.Ile357Met in Patients With Hemolytic Uremic Syndrome,” was published…

Soliris (eculizumab) appears to be more effective in atypical hemolytic uremic syndrome (aHUS) patients with complement abnormalities, than in those whose disease was triggered by other underlying conditions, a 20-year retrospective analysis has found. The risk of disease relapse over the course of five years was 40% higher…

Soliris (eculizumab) and hemodialysis improved kidney function in a man with end-stage kidney disease who was diagnosed with atypical hemolytic uremic syndrome (aHUS) after a kidney transplant, according to a case study from South Korea. The report “emphasizes the importance of primary kidney disease evaluation and careful monitoring”…

The case of a 69-year-old-woman with atypical hemolytic uremic syndrome (aHUS) who carried mutations in the CFI and the DGKE genes that hadn’t previously been associated with the disease, was described in a recent report. The woman responded well to treatment with…

An 11-year-old boy was diagnosed with atypical hemolytic uremic syndrome (aHUS) after having symptoms that included a hard-to-treat headache, low appetite, fever, and shortness of breath, according to a case report from Nepal. His symptoms underscore the need for a “multidisciplinary approach … for aHUS due to its rarity…

A teenager with a mutation in the C3 gene developed atypical hemolytic uremic syndrome (aHUS), which manifested as bleeding in the lungs, after undergoing kidney transplant surgery. According to clinicians, a correct and timely diagnosis in a case like this is essential for improving treatment outcomes. “In patients presenting…

A delay in diagnosing and treating a woman with pregnancy-related atypical hemolytic uremic syndrome (aHUS) may have contributed to her kidney failure, a U.S. case study suggests. Her condition was first thought to be thrombotic thrombocytopenic purpura (TTP), a related blood disorder. Until she was finally diagnosed correctly…

Intensive treatment with anti-vascular endothelial growth factor (anti-VEGF) medications — commonly used to treat disorders causing vision impairments — are thought to have led to the onset of atypical hemolytic uremic syndrome (aHUS) in a man in his 40s. It is a rare finding in an extremely rare disease,…