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In cases of atypical hemolytic uremic syndrome (aHUS) that develop following pregnancy and childbirth, getting an early diagnosis is important for appropriate and timely treatment and better outcomes, a case report highlights. “A prompt and accurate diagnosis is critical in these patients to initiate early treatment, which can significantly…

An 11-year-old boy was diagnosed with atypical hemolytic uremic syndrome (aHUS) after having symptoms that included a hard-to-treat headache, low appetite, fever, and shortness of breath, according to a case report from Nepal. His symptoms underscore the need for a “multidisciplinary approach … for aHUS due to its rarity…

A COVID-19 vaccine may have triggered the development of two autoimmune diseases, atypical hemolytic uremic syndrome (aHUS) and antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), which are associated with damage to small blood vessels and the kidneys, in a 67-year-old man three weeks after vaccination, according to a case…

The case of a woman who developed atypical hemolytic uremic syndrome (aHUS) following pregnancy highlights the importance of an early diagnosis and prompt treatment of the disease. As many as 20% of aHUS cases occur in people who are pregnant or have just given birth, referred to as…

Treatment with Soliris (eculizumab) helped about half of the children diagnosed with atypical hemolytic uremic syndrome (aHUS) after they received a stem cell transplant, according to a small study. Among 13 patients who started taking Soliris, seven survived and saw their disease-associated biomarkers normalize. Six died due to complications…

A team of five experts from across Spain got together to reach a consensus on a set of recommendations for how to best manage atypical hemolytic uremic syndrome (aHUS) in adults. The consensus offers guidance for doctors with less experience in managing the disease. It covers the entire patient…

A teenager with a mutation in the C3 gene developed atypical hemolytic uremic syndrome (aHUS), which manifested as bleeding in the lungs, after undergoing kidney transplant surgery. According to clinicians, a correct and timely diagnosis in a case like this is essential for improving treatment outcomes. “In patients presenting…

A delay in diagnosing and treating a woman with pregnancy-related atypical hemolytic uremic syndrome (aHUS) may have contributed to her kidney failure, a U.S. case study suggests. Her condition was first thought to be thrombotic thrombocytopenic purpura (TTP), a related blood disorder. Until she was finally diagnosed correctly…

A rare mutation in the CFHR5 gene may have led to the excessive activation of the immune complement system, triggering atypical hemolytic uremic syndrome (aHUS) in a 5-year-old girl, a case study reports. The mutation in CFHR5 (which stands for complement factor H-related protein 5) was found to reduce…

A mutation in the complement factor I (CFI) gene can lead in rare cases to both atypical hemolytic uremic syndrome (aHUS) and C3 glomerulopathy, two complement-mediated kidney diseases, a case study in Japan shows. “Overlapping [aHUS] and C3 glomerulopathy with complement factor I mutation is very rare, especially in…