Soliris (eculizumab) appears to be more effective in atypical hemolytic uremic syndrome (aHUS) patients with complement abnormalities, than in those whose disease was triggered by other underlying conditions, a 20-year retrospective analysis has found. The risk of disease relapse over the course of five years was 40% higher…
The case of a 49-year-old man with atypical hemolytic uremic syndrome (aHUS) that manifested after he developed pancreatitis was described in a recent report. Genetic testing showed the man had a mutation in the MCP gene, a known risk factor for aHUS. The fact that he hadn’t had any…
Soliris (eculizumab) and hemodialysis improved kidney function in a man with end-stage kidney disease who was diagnosed with atypical hemolytic uremic syndrome (aHUS) after a kidney transplant, according to a case study from South Korea. The report “emphasizes the importance of primary kidney disease evaluation and careful monitoring”…
Colombian children seen for the first time for atypical hemolytic uremic syndrome (aHUS) had a high frequency of disease manifestations involving organs other than the kidneys, with two-thirds showing signs of lung involvement, a study reports. Their prognosis was worse than reported in previous studies, with more than half…
At the onset of atypical hemolytic uremic syndrome (aHUS) among children in India, high levels of antibodies against a complement protein called factor B were tied to disease severity, a new study by researchers in New Delhi revealed. Importantly, all pediatric patients with genetic mutations associated with aHUS did…
The case of a 69-year-old-woman with atypical hemolytic uremic syndrome (aHUS) who carried mutations in the CFI and the DGKE genes that hadn’t previously been associated with the disease, was described in a recent report. The woman responded well to treatment with…
An 8-year-old girl was diagnosed with a rare case of atypical hemolytic uremic syndrome (aHUS) and cardiac arrhythmias, or abnormal heartbeats, according to a recent report from Turkey. While known for its damage to the kidneys, aHUS can affect the heart, with cases of heart muscle disease and heart failure…
In cases of atypical hemolytic uremic syndrome (aHUS) that develop following pregnancy and childbirth, getting an early diagnosis is important for appropriate and timely treatment and better outcomes, a case report highlights. “A prompt and accurate diagnosis is critical in these patients to initiate early treatment, which can significantly…
An 11-year-old boy was diagnosed with atypical hemolytic uremic syndrome (aHUS) after having symptoms that included a hard-to-treat headache, low appetite, fever, and shortness of breath, according to a case report from Nepal. His symptoms underscore the need for a “multidisciplinary approach … for aHUS due to its rarity…
A COVID-19 vaccine may have triggered the development of two autoimmune diseases, atypical hemolytic uremic syndrome (aHUS) and antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), which are associated with damage to small blood vessels and the kidneys, in a 67-year-old man three weeks after vaccination, according to a case…
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