A COVID-19 vaccine may have triggered the development of two autoimmune diseases, atypical hemolytic uremic syndrome (aHUS) and antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), which are associated with damage to small blood vessels and the kidneys, in a 67-year-old man three weeks after vaccination, according to a case…
News
The case of a woman who developed atypical hemolytic uremic syndrome (aHUS) following pregnancy highlights the importance of an early diagnosis and prompt treatment of the disease. As many as 20% of aHUS cases occur in people who are pregnant or have just given birth, referred to as…
Treatment with Soliris (eculizumab) helped about half of the children diagnosed with atypical hemolytic uremic syndrome (aHUS) after they received a stem cell transplant, according to a small study. Among 13 patients who started taking Soliris, seven survived and saw their disease-associated biomarkers normalize. Six died due to complications…
A team of five experts from across Spain got together to reach a consensus on a set of recommendations for how to best manage atypical hemolytic uremic syndrome (aHUS) in adults. The consensus offers guidance for doctors with less experience in managing the disease. It covers the entire patient…
A teenager with a mutation in the C3 gene developed atypical hemolytic uremic syndrome (aHUS), which manifested as bleeding in the lungs, after undergoing kidney transplant surgery. According to clinicians, a correct and timely diagnosis in a case like this is essential for improving treatment outcomes. “In patients presenting…
A delay in diagnosing and treating a woman with pregnancy-related atypical hemolytic uremic syndrome (aHUS) may have contributed to her kidney failure, a U.S. case study suggests. Her condition was first thought to be thrombotic thrombocytopenic purpura (TTP), a related blood disorder. Until she was finally diagnosed correctly…
A rare mutation in the CFHR5 gene may have led to the excessive activation of the immune complement system, triggering atypical hemolytic uremic syndrome (aHUS) in a 5-year-old girl, a case study reports. The mutation in CFHR5 (which stands for complement factor H-related protein 5) was found to reduce…
A mutation in the complement factor I (CFI) gene can lead in rare cases to both atypical hemolytic uremic syndrome (aHUS) and C3 glomerulopathy, two complement-mediated kidney diseases, a case study in Japan shows. “Overlapping [aHUS] and C3 glomerulopathy with complement factor I mutation is very rare, especially in…
Intensive treatment with anti-vascular endothelial growth factor (anti-VEGF) medications — commonly used to treat disorders causing vision impairments — are thought to have led to the onset of atypical hemolytic uremic syndrome (aHUS) in a man in his 40s. It is a rare finding in an extremely rare disease,…
Alexion, AstraZeneca Rare Disease signed off on a letter of intent in Canada that brings Ultomiris (ravulizumab) — approved in the country for certain people with atypical hemolytic uremic syndrome (aHUS) — a step closer to becoming available under public drug plans. The letter, to the pan-Canadian Pharmaceutical…
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