News

Epysqli (eculizumab-aagh), a biosimilar of Soliris (eculizumab), is now available for patients in the U.S., according to an announcement from Samsung Bioepis and Teva Pharmaceuticals. The biosimilar is authorized to treat people with atypical hemolytic uremic syndrome (aHUS), as well as paroxysmal nocturnal hemoglobinuria, and…

A woman with lupus in her early 30s, who developed atypical hemolytic uremic syndrome (aHUS) after pregnancy, was not suspected of having the rare condition until five days after her baby’s birth, which resulted in her not receiving the correct treatment, according to a case report from researchers in…

COVID-19 was the likely trigger of atypical hemolytic uremic syndrome (aHUS) in a boy found to carry a mutation that reduced the levels of an immune protein called CD46, which may have increased his chance of developing the disease, according to a report from Iran. The boy first improved…

Atypical hemolytic uremic syndrome (aHUS) can be a rare complication of a procedure to remove gallstones, according to a report in the U.S. that describes the case of a teenage girl who developed the condition secondary to post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis. The study, “Atypical hemolytic…

Early plasma exchange therapy followed by Ultomiris  (ravulizumab) treatment successfully managed atypical hemolytic uremic syndrome (aHUS) in an 83-year-old woman, according to a report from Japan. The woman started showing symptoms of aHUS after a bone fracture. Genetic testing revealed she had a mutation in the CFI gene,…

The pregnancy-related complication HELLP syndrome — fully known as hemolysis, elevated liver enzymes, and low platelets syndrome, which causes high blood pressure and organ damage — is sometimes confused with atypical hemolytic uremic syndrome, or aHUS, a rare disease in which kidney dysfunction persists for a long time, especially…

Soliris (eculizumab) largely reduces the risk of long-term kidney problems in women who develop atypical hemolytic uremic syndrome (aHUS) during or after pregnancy, a meta-analysis study has found. “This analysis highlights the severe kidney and pregnancy outcomes associated with [pregnancy-associated aHUS],” researchers wrote, noting Soliris treatment is beneficial…

An interactive electronic storybook, or e-book, designed to help children with atypical hemolytic uremic syndrome (aHUS) better understand their rare disease, has been launched by Alexion, AstraZeneca Rare Disease, which markets two aHUS therapies. Called “Revealing the Secrets of aHUS,” the fantasy e-book uses imaginative play to…

Timely diagnosis and aggressive treatment were crucial for the recovery of a 26-year-old woman who was diagnosed with atypical hemolytic uremic syndrome (aHUS) after she was induced at 30 weeks of pregnancy, researchers in China report. “Clinical data and treatment experiences related to pregnancy-associated aHUS remain limited. This…

In a “challenging case,” clinicians found a mutation in the membrane cofactor protein gene, or MCP/CD46, in a 23-year-old man with atypical hemolytic uremic syndrome (aHUS). In reporting the case, the researchers stressed the “critical role of genetic testing” in patient evaluations, highlighting the need to be aware of…