Author Archives: Marta Figueiredo PhD

Boosting Cell Stress Response May Be Therapeutic Approach in aHUS

Endothelial cells, or those that line blood vessels, are functionally abnormal in people with atypical hemolytic uremic syndrome (aHUS) associated with antibodies against complement factor H or CFH, according to a small study using patient-derived cells. Notably, these intrinsic defects were associated with reduced activation of the p38 MAPK…

Phase 3 Trials Will Test Self-injectable Crovalimab

Two Phase 3 clinical trials will evaluate the safety and effectiveness of Roche’s investigational, self-injectable therapy crovalimab (RG6107) in children, adolescents, and adults with atypical hemolytic uremic syndrome (aHUS). The first trial, called COMMUTE-a (NCT04861259), already is recruiting aHUS patients, ages 12 and older, at sites in the…

Rare Case of aHUS Found in Man with Lipoprotein Glomerulopathy

Researchers have reported a rare case of atypical hemolytic uremic syndrome (aHUS) in a 21-year-old Swiss-Indonesian man with lipoprotein glomerulopathy (LPG), an inherited kidney disease associated with fat accumulation in the organ’s small blood vessels. The findings suggest that the later development of aHUS, which also affects the kidney’s…

Ultomiris Available Soon for Eligible aHUS Patients in England

Alexion Pharmaceuticals’ long-acting Ultomiris (ravulizumab) was added to the list of medications available through England’s national health service (NHS) to adults and children weighing at least 10 kilograms (22 pounds), with atypical hemolytic uremic syndrome (aHUS). Ultomiris is Alexion’s successor to Soliris (eculizumab) — also approved for aHUS and…