Marisa Wexler, MS, senior science writer —

A case study of atypical hemolytic uremic syndrome (aHUS) caused by a new mutation in the DGKE gene highlights the disease’s early onset and severe difficult-to-treat course. The report, “Clinical features and management of atypical hemolytic uremic syndrome patient with DGKE gene variants: a case report,”…

A young adult with atypical hemolytic uremic syndrome (aHUS) in India successfully received a transplanted kidney from a donor with an incompatible blood type, a recent case study says. The report — the first to document such a case in someone diagnosed with aHUS — demonstrates that blood-type-incompatible…

A boy with atypical hemolytic uremic syndrome (aHUS) experienced a disease relapse followed by unusual symptoms, including bone tissue death and gallstones, after pausing treatment with Soliris (eculizumab). His case was described in the report, “Bilateral hip osteonecrosis and cholelithiasis after eculizumab discontinuation in atypical…

People with atypical hemolytic uremic syndrome (aHUS) who start treatment with Soliris (eculizumab) or Ultomiris (ravulizumab) — both marketed by Alexion — generally use fewer healthcare resources, according to a new U.S. study. Indeed, rates of insurance claims for aHUS patients starting on either therapy dropped substantially…

For the first time in South Korea, a patient who developed atypical hemolytic uremic syndrome (aHUS) after undergoing a kidney transplant was successfully treated with Soliris (eculizumab). “We report the first successful case of aHUS treatment in a kidney transplant recipient with early use of [Soliris] in South…

About half of the atypical hemolytic uremic syndrome (aHUS) patients had clinically relevant anxiety and more than a quarter met the criteria for post-traumatic stress disorder (PTSD), according to a recent study. “Our cross-sectional survey done a median of [six] years after acute … aHUS demonstrated a substantial burden…

Soliris (eculizumab) was effective in managing atypical hemolytic uremic syndrome (aHUS), which arose in a man as a side effect of chemotherapy treatment with gemcitabine. “The mainstay management decision [for gemcitabine-related aHUS] is the prompt discontinuation of gemcitabine therapy, and while this is effective in some patients, complement…

A substantial number of people with atypical hemolytic uremic syndrome (aHUS) carry rare structural variations in a part of the genome called the CFH-CFHR region and some variants are linked to certain disease manifestations, a recent study reports. “This work highlights the association between aHUS and genomic rearrangements in…

The demographics of people hospitalized for hemolytic uremic syndrome (HUS) in the U.S. have shifted over the last decade, with a lower proportion of young children and a higher number of Black patients, a new study reports. “Further surveillance is required to determine if these trends continue,” the researchers wrote.

Soliris (eculizumab) can safely be discontinued in children with atypical hemolytic uremic syndrome (aHUS) whose disease is in remission, but close monitoring is necessary due to the possibility of aHUS recurrence, a recent study in the Arabian Gulf region highlights. The study found that more than 70% of…