A 21-year-old man with atypical hemolytic uremic syndrome (aHUS) associated with Castleman disease improved after receiving treatment with iptacopan and Sylvant (siltuximab), according to a case report. Castleman disease presents symptoms that mimic aHUS due to the overgrowth of lymph nodes. Iptacopan is marketed as Fabhalta for…
The case of a 29-year-old woman who developed pregnancy-associated atypical hemolytic uremic syndrome (aHUS) along with uncommon lung complications after giving birth by cesarean section was reported in Mexico. Despite in-hospital complications, initial management that included corticosteroids yielded favorable results, although the woman still had significant kidney damage requiring hemodialysis,…
People with atypical hemolytic uremic syndrome (aHUS) who completed self-assessments for a study scored lower on measures of physical and cognitive functioning than the general population. Patients reported higher levels of fatigue, anxiety, depression, and sleep disturbances, with “chronically impaired global health status,” the researchers wrote in what they…
A 26-year-old woman who developed pregnancy-associated atypical hemolytic uremic syndrome (p-aHUS) successfully recovered following treatment with Soliris (eculizumab), according to a case report from China. This case provides “a valuable reference for the timing, efficacy, and safety of complement blockade in p-aHUS [pregnancy-associated aHUS],” according to researchers. They added that the “successful…
A 29-year-old woman in the U.S. showed signs of atypical hemolytic uremic syndrome (aHUS) and a C2 gene mutation, but without infection caused by Shiga toxin-producing Escherichia coli (STEC), according to a case report. STEC bacteria are the cause of the typical form of the disease. Genetic testing could…
Switching from Soliris (eculizumab) to Ultomiris (ravulizumab) is a safe and effective treatment strategy for people with atypical hemolytic uremic syndrome (aHUS), according to a real-world study in Japan. The treatment switch was associated with stable levels of blood and kidney-related disease markers, preventing disease relapse or…
Atypical hemolytic uremic syndrome (aHUS) may be triggered by acute inflammation of the pancreas, or pancreatitis, a team of researchers from India highlighted in a report describing the case of a 36-year-old man with both conditions. The man sought medical attention due to abdominal pain and was found to…
More than half of people with atypical hemolytic uremic syndrome (aHUS) in India have self-reactive antibodies targeting complement factor H (CFH), a protein that regulates the activity of the complement system, according to a recent study. These patients generally had better outcomes, being less likely to develop end-stage…
Plasma exchange therapy successfully managed atypical hemolytic uremic syndrome (aHUS) triggered by pancreas inflammation in a 72-year-old man, according to a case report from China. However, discontinuation of plasma exchange and a transition to hemodialysis — a treatment used to remove waste and excessive fluid from the blood when…
Early plasma exchange therapy followed by Ultomiris  (ravulizumab) treatment successfully managed atypical hemolytic uremic syndrome (aHUS) in an 83-year-old woman, according to a report from Japan. The woman started showing symptoms of aHUS after a bone fracture. Genetic testing revealed she had a mutation in the CFI gene,…
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