Two diseases often difficult for doctors to distinguish between — atypical hemolytic uremic syndrome (aHUS) and thrombotic thrombocytopenic purpura (TTP) — are both marked by complement system activation and severe deficiency of the ADAMTS13 enzyme, researchers report. These disorders are known to share symptoms, but until now were largely…
Treatment with plasma exchange (PEX) was safe, restored kidney function and led to no requirement of dialysis at three months in most children with atypical hemolytic uremic syndrome (aHUS), according to research from India. The study, “Membrane-filtration based plasma exchanges for atypical hemolytic uremic syndrome: Audit…
A pregnant woman who came to a hospital complaining of a variety of ills was diagnosed with atypical hemolytic uremic syndrome (aHUS) through genetic testing in a process described in a case report, and responded well to treatment with Soliris (eculizumab). The case study, “Diagnosis of atypical…
Treatment with Ultomiris (ravulizumab-cwvz) normalized platelet counts, eased hemolysis (destruction of red blood cells), and improved kidney function in a Phase 3 trial in patients with atypical hemolytic uremic syndrome (aHUS) who had not been treated with complement inhibitors. Specifically, 53.6% of patients showed complete thrombotic microangiopathy (TMA)…
A new case report described a baby with respiratory failure who was diagnosed with atypical hemolytic uremic syndrome (aHUS) after suspicion of Streptococcus pneumoniae (SPN)-induced HUS (pHUS). The study, “A Case of Suspected Streptococcus Pneumoniae Hemolytic Uremic Syndrome (pHUS) with Utilization of Minor Crossmatching for Platelet…
A rare case report described a woman with genetic and clinical evidence of atypical hemolytic uremic syndrome (aHUS), along with Alport syndrome and pauci-immune crescentic glomerulonephritis (PCGN), suggesting a shared disease mechanism among the three renal conditions. The study, “A rare case of Alport syndrome,…
Extra-renal manifestations in children with atypical hemolytic uremic syndrome (aHUS) are most common in the central nervous system (CNS), a study has found. According to the study, these neurological symptoms are associated with higher mortality and worse kidney function. The findings also revealed the beneficial effects of treatment with…
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